The science behind Mind the Byte

We are committed to publish the highest quality research works for the benefit of the scientific community. Most of our original articles are the result of collaborations with our academic partners.
STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis. Priego N, Zhu L, Monteiro C, Mulders M, Wasilewski D, Bindeman W, Doglio L, Martínez L, Martínez-Saez E, Cajal SRY, Megías D, Hernández-Encinas E, Blanco-Aparicio C, Martínez L, Zarzuela E, Muñoz J, Fustero-Torres C, Pineiro E, Hernández-Laín A, Bertero L, Poli V, Sánchez-Martínez M, Menendez JA, Soffietti R, Bosch-Barrera J, Valiente M. Nat Med. 2018 Jun 11. doi: 10.1038/s41591-018-0044-4.

Decarboxylation of Ang-(1-7) to Ala1-Ang-(1-7) leads to significant changes in pharmacodynamics. Tetzner A, Naughton M, Gebolys K, Eichhorst J, Sala E, Villacañas Ó, Walther T. Eur J Pharmacol. 2018 May 21;833:116-123. doi: 10.1016/j.ejphar.2018.05.031.

Metformin directly targets the H3K27me3 demethylase KDM6A/UTX. Cuyàs E, Verdura S, Llorach-Pares L, Fernández-Arroyo S, Luciano-Mateo F, Cabré N, Stursa J, Werner L, Martin-Castillo B, Viollet B, Neuzil J, Joven J, Nonell-Canals A, Sanchez-Martinez M, Menendez JA. Aging Cell. 2018 May 8:e12772. doi: 10.1111/acel.12772.

Silibinin is a direct inhibitor of STAT3. Verdura S, Cuyàs E, Llorach-Parés L, Pérez-Sánchez A, Micol V, Nonell-Canals A, Joven J, Valiente M, Sánchez-Martínez M, Bosch-Barrera J, Menendez JA. Food Chem Toxicol. 2018 Jun;116(Pt B):161-172. doi: 10.1016/j.fct.2018.04.028.
Extra-virgin olive oil contains a metabolo-epigenetic inhibitor of cancer stem cells. Corominas-Faja B, Cuyàs E, Lozano-Sánchez J, Cufí S, Verdura S, Fernández-Arroyo S, Borrás-Linares I, Martin-Castillo B, Martin ÁG, Lupu R, Nonell-Canals A, Sanchez-Martinez M, Micol V, Joven J, Segura-Carretero A, Menendez JA. Carcinogenesis. 2018 Apr 5;39(4):601-613. doi: 10.1093/carcin/bgy023.
Computer-Aided Drug Design Applied to Marine Drug Discovery: Meridianins as Alzheimer’s Disease Therapeutic Agents. Llorach-Pares L, Nonell-Canals A, Sanchez-Martinez M, Avila C. Mar Drugs. 2017 Nov 27;15(12). pii: E366. doi: 10.3390/md15120366.
Amyloid-induced β-cell dysfunction and islet inflammation are ameliorated by 4-phenylbutyrate (PBA) treatment. Montane J, de Pablo S, Castaño C, Rodríguez-Comas J, Cadavez L, Obach M, Visa M, Alcarraz-Vizán G, Sanchez-Martinez M, Nonell-Canals A, Parrizas M, Servitja JM, Novials A. FASEB J. 2017 Dec;31(12):5296-5306. doi: 10.1096/fj.201700236R.
Chemically synthesized peptide libraries as a new source of BBB shuttles. Use of mass spectrometry for peptide identification. Guixer B, Arroyo X, Belda I, Sabidó E, Teixidó M, Giralt E. J Pept Sci. 2016 Sep;22(9):577-91. doi: 10.1002/psc.2900.
G-Protein-Coupled Receptor MrgD Is a Receptor for Angiotensin-(1-7) Involving Adenylyl Cyclase, cAMP, and Phosphokinase A. Tetzner A, Gebolys K, Meinert C, Klein S, Uhlich A, Trebicka J, Villacañas Ó, Walther T. Hypertension. 2016 Jul;68(1):185-94. doi: 10.1161/HYPERTENSIONAHA.116.07572.
Boehmeriasin A as new lead compound for the inhibition of topoisomerases and SIRT2. Christodoulou MS, Calogero F, Baumann M, García-Argáez AN, Pieraccini S, Sironi M, Dapiaggi F, Bucci R, Broggini G, Gazzola S, Liekens S, Silvani A, Lahtela-Kakkonen M, Martinet N, Nonell-Canals A, Santamaría-Navarro E, Baxendale IR, Dalla Via L, Passarella D. Eur J Med Chem. 2015 Mar 6;92:766-75. doi: 10.1016/j.ejmech.2015.01.038.